Benactyzine

Benactyzine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	BR: Class C1 (Other controlled substances); In general: ℞ (Prescription only);
Identifiers
	IUPAC name 2-(diethylamino)ethyl hydroxy(diphenyl)acetate;
CAS Number	302-40-9 ;
PubChem CID	9330;
DrugBank	DB09023 ;
ChemSpider	8966 ;
UNII	595EG71R3F;
KEGG	D07498 ;
ChEMBL	ChEMBL70352 ;
CompTox Dashboard (EPA)	DTXSID0022644 ;
ECHA InfoCard	100.005.568
Chemical and physical data
Formula	C20H25NO3
Molar mass	327.424 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCCN(CC)CC)C(O)(c1ccccc1)c2ccccc2;
	InChI InChI=1S/C20H25NO3/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,3-4,15-16H2,1-2H3 ; Key:IVQOFBKHQCTVQV-UHFFFAOYSA-N ;
	(what is this?) (verify)

Benactyzine is an anticholinergic drug that was used in the treatment of clinical depression and anxiety disorders before it was pulled from the U.S. market by the FDA due to serious side effects.^[2]

Its use for these indications was limited by side effects such as dry mouth and nausea, and at high doses it can cause more severe symptoms such as deliriant and hallucinogenic effects.^[2] "Large doses of benactyzine in normal subjects may produce a state resembling the action of mescaline or LSD."^[3]

Brand names have included: Suavitil, Phebex, Phobex, Cedad, Cevanol, Deprol, Lucidil, Morcain, Nutinal, Parasan. While there was some tentative evidence of effectiveness when combined with meprobamate, with the medication no longer available it is not clinically important.^[4]

History

Benactyzine was brought to market in the US in 1957 by Merck under the tradename, Suavitil.^[5]

References

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ ^a ^b Shorter E (December 2002). "Looking backwards: a possible new path for drug discovery in psychopharmacology". Nature Reviews. Drug Discovery. 1 (12): 1003–1006. doi:10.1038/nrd964. PMID 12461521. S2CID 23439533.
^ Fisher S (1959). Child Research In Psychopharmacology (1st ed.). Springfield, Illinois: Charles C Thomas Pub. p. 13.
^ DeBattista AF, Schatzberg JO, Cole C (2010). Manual of clinical psychopharmacology (7th ed.). Washington, DC: American Psychiatric Pub. p. 423. ISBN 978-1-58562-377-8.
^ Smith MC (2013). "Market Behavior". Principles of Pharmaceutical Marketing (Third ed.). New York: Routledge. ISBN 978-1-317-94071-5.

External links

Media related to Benactyzine at Wikimedia Commons

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[Shorter_2002-2] Shorter E (December 2002). "Looking backwards: a possible new path for drug discovery in psychopharmacology". Nature Reviews. Drug Discovery. 1 (12): 1003–1006. doi:10.1038/nrd964. PMID 12461521. S2CID 23439533.

[3] Fisher S (1959). Child Research In Psychopharmacology (1st ed.). Springfield, Illinois: Charles C Thomas Pub. p. 13.

[4] DeBattista AF, Schatzberg JO, Cole C (2010). Manual of clinical psychopharmacology (7th ed.). Washington, DC: American Psychiatric Pub. p. 423. ISBN 978-1-58562-377-8.

[5] Smith MC (2013). "Market Behavior". Principles of Pharmaceutical Marketing (Third ed.). New York: Routledge. ISBN 978-1-317-94071-5.

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Anxiolytics (N05B)
5-HT_1ARTooltip 5-HT1A receptor agonists	Buspirone Gepirone Tandospirone
GABA_ARTooltip GABAA receptor PAMsTooltip positive allosteric modulators	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Carisoprodol Chlormezanone^‡ Ethanol (alcohol) Etifoxine
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIsTooltip Selective serotonin reuptake inhibitors (e.g., escitalopram) SNRIsTooltip Serotonin-norepinephrine reuptake inhibitors (e.g., duloxetine) SARIsTooltip Serotonin antagonist and reuptake inhibitors (e.g., trazodone) TCAsTooltip Tricyclic antidepressants (e.g., clomipramine^#) TeCAsTooltip Tetracyclic antidepressants (e.g., mirtazapine) MAOIsTooltip Monoamine oxidase inhibitors (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol, atenolol, betaxolol, nadolol, oxprenolol, pindolol)
Others	Benzoctamine Cycloserine Fabomotizole Hydroxyzine Lorpiprazole Mebicar Mepiprazole Nicotine (tobacco) Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

History

See also

References

External links