Fluetonitazene

Fluetonitazene
Identifiers
	IUPAC name N,N-diethyl-2-[2-[[4-(2-fluoroethoxy)phenyl]methyl]-5-nitrobenzimidazol-1-yl]ethanamine;
PubChem CID	172332078;
Chemical and physical data
Formula	C22H27FN4O3
Molar mass	414.481 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)CCN1C2=C(C=C(C=C2)[N+](=O)[O-])N=C1CC3=CC=C(C=C3)OCCF;
	InChI InChI=1S/C22H27FN4O3/c1-3-25(4-2)12-13-26-21-10-7-18(27(28)29)16-20(21)24-22(26)15-17-5-8-19(9-6-17)30-14-11-23/h5-10,16H,3-4,11-15H2,1-2H3; Key:XCWWXPKOMYPTRP-UHFFFAOYSA-N;

Fluetonitazene (Fluornitrazene, F-Etonitazene, 2-Fluoroetonitazene) is a benzimidazole derivative which is an opioid designer drug. It was patented in 2024 as a potential novel analgesic,^[1] but appeared on the illicit market at around the same time, first being identified in Germany in March 2024.^[2]^[3] It is a potent opioid agonist in vitro with similar potency to N-Desethyletonitazene.^[4]

References

^ WO 2024/196438, Michaelides M, Gomez JL, Rice KC, Sulima A, Baumann MH, "Fluorinated mu-opioid receptor agonists", published 26 September 2024, assigned to The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
^ "Fluetonitazene" (PDF). EU Early Warning System Formal Notification. European Union Drugs Agency (EUDA). 14 May 2024.
^ "Increasing availability of nitazenes calls for global response". Early Warning Advisory (EWA). United Nations Office on Drugs and Crime (UNODC). February 2025.
^ Kozell LB, Eshleman AJ, Wolfrum KM, Swanson TL, Schutzer KA, Schutzer WE, et al. (September 2025). "Pharmacology of newly identified nitazene variants reveals structural determinants of affinity, potency, selectivity for mu opioid receptors". Neuropharmacology. 276 110512. doi:10.1016/j.neuropharm.2025.110512. PMC 12147671. PMID 40374158.

[1] WO 2024/196438, Michaelides M, Gomez JL, Rice KC, Sulima A, Baumann MH, "Fluorinated mu-opioid receptor agonists", published 26 September 2024, assigned to The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

[2] "Fluetonitazene" (PDF). EU Early Warning System Formal Notification. European Union Drugs Agency (EUDA). 14 May 2024.

[3] "Increasing availability of nitazenes calls for global response". Early Warning Advisory (EWA). United Nations Office on Drugs and Crime (UNODC). February 2025.

[Kozell_2025-4] Kozell LB, Eshleman AJ, Wolfrum KM, Swanson TL, Schutzer KA, Schutzer WE, et al. (September 2025). "Pharmacology of newly identified nitazene variants reveals structural determinants of affinity, potency, selectivity for mu opioid receptors". Neuropharmacology. 276 110512. doi:10.1016/j.neuropharm.2025.110512. PMC 12147671. PMID 40374158.

[1]

[2]

[3]

[4]

See also

References