5-TFMO-DMT
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| Other names | 5-OCF3-DMT |
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| Formula | C13H15F3N2O |
| Molar mass | 272.271 g·mol−1 |
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5-TFMO-DMT (5-(trifluoromethoxy)-DMT, 5-OCF3-DMT, 5-(trifluoromethoxy)-N,N-dimethyltryptamine) is a psychedelic tryptamine derivative related to drugs such as 5-MeO-DMT and DMT (DMT). It acts as an agonist at the 5-HT2A receptor with an EC50 of 127.2 nM.[1] It was shown to release serotonin (5-HT) from synaptosomal preparations, and to reduce immobility time in the forced-swim test in animal studies, suggesting that it might have antidepressant activity.[1]
See also
References
- ^ a b WO 2022/235927, Kruegel AC, "NOVEL TRYPTAMINES AND METHODS OF TREATING MOOD DISORDERS.", published 10 November 2022, assigned to Gilgamesh Pharmaceuticals, Inc..
| DRAsTooltip Dopamine releasing agents |
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| NRAsTooltip Norepinephrine releasing agents |
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See also: Receptor/signaling modulators • Monoamine reuptake inhibitors • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins | |||||||||||||||
| Tryptamines |
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| 4-Hydroxytryptamines and esters/ethers |
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| 5-Hydroxy- and 5-methoxytryptamines |
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| N-Acetyltryptamines |
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| α-Alkyltryptamines |
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| Cyclized tryptamines |
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| Isotryptamines | |
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