2021 MUSC Health Women's Open – Singles

Singles
2021 MUSC Health Women's Open
Champion	Astra Sharma
Runner-up	Ons Jabeur
Score	2–6, 7–5, 6–1
Draw	32 (4 Q / 3 WC)
Seeds	8

Astra Sharma won her first WTA Tour singles title, defeating Ons Jabeur in the final of the second 2021 Charleston Open, 2–6, 7–5, 6–1.^[1]

The second tournament was the 50th edition of the Charleston Open that featured featuring consecutive events, with the 2021 Volvo Car Open being the first. The second Charleston tournament was organised with a single-year license in 2021.^[2]

	Semifinals							Final
	1	Ons Jabeur	6	6
		Danka Kovinić	3	0
								1	Ons Jabeur	6	5	1
									Astra Sharma	2	7	6
		Astra Sharma	77	6
	SE	Camila Osorio	65	1

	First round							Second round							Quarterfinals							Semifinals
	1	O Jabeur	6	6
		S Vögele	4	1				1	O Jabeur	6	6
	Q	A Parks	6	6				Q	A Parks	4	0
	Q	G Min	1	4											1	O Jabeur	6	6
		K Ahn	66	2												N Hibino	0	1
		F Di Lorenzo	78	6					F Di Lorenzo	4	3
		N Hibino	7	5	6				N Hibino	6	6
	5	M Doi	5	7	6r																	1	O Jabeur	6	6
	3	S Rogers	6	6																			D Kovinić	3	0
		C McNally	0	1				3	S Rogers	6	6
	Q	C Liu	7	4	6			Q	C Liu	2	2
	Q	S Sanders	5	6	0										3	S Rogers	5	1
		D Kovinić	6	6												D Kovinić	7	6
		V Tomova	3	3					D Kovinić	6	1	6
	WC	C Vandeweghe	63	4				7	L Davis	1	6	3
	7	L Davis	77	6

	First round							Second round							Quarterfinals							Semifinals
	8	M Brengle	6	3	6
		N Vikhlyantseva	0	6	2			8	M Brengle	4	6	5
		Y Wang	4	2					A Sharma	6	4	7
		A Sharma	6	6												A Sharma	6	6
		T Martincová	3	2r											WC	L Fruhvirtová	4	3
	WC	E Navarro	6	3				WC	E Navarro	4	2
	WC	L Fruhvirtová	6	67	4			WC	L Fruhvirtová	6	6
	4	A Cornet	2	79	4r																		A Sharma	77	6
	6	A Tomljanović	6	6																		SE	C Osorio	65	1
		R Zarazúa	1	1				6	A Tomljanović	1	4
		C Tauson	6	6					C Tauson	6	6
		L Samsonova	3	3												C Tauson	4	0r
		C McHale	77	6											SE	C Osorio	6	1
		S Errani	63	3					C McHale	6	62	61
	SE	C Osorio	6	4	7			SE	C Osorio	2	77	77
	2	M Linette	3	6	5

	First round							Qualifying competition
	Alt	Hailey Baptiste	4	0r
		Claire Liu	6	3
									Claire Liu	2	6	6
								Alt	Ellen Perez	6	4	0
	Alt	Ellen Perez	61	77	7
	6	Usue Maitane Arconada	77	61	5

	First round							Qualifying competition
	Alt	Katharina Gerlach	3	2
		Storm Sanders	6	6
									Storm Sanders	77	6
								7	Kurumi Nara	64	2
		Whitney Osuigwe	2	0
	7	Kurumi Nara	6	6

	First round							Qualifying competition
	Alt	Alycia Parks	6	6
	PR	Varvara Flink	3	3
								Alt	Alycia Parks	3	6	6
								Alt	Kateryna Bondarenko	6	3	3
	WC	Kennedy Shaffer	1	7	2
	Alt	Kateryna Bondarenko	6	5	6

	First round							Qualifying competition
	4	Leonie Küng	3	4
	WC	Gabriella Price	6	6
								WC	Gabriella Price	0	4
								Alt	Grace Min	6	6
	Alt	Grace Min	77	2	7
	5	Caroline Dolehide	64	6	5

• Main Draw
• Qualifying Draw