Trolnitrate
Names
IUPAC name
2-[bis(2-nitrooxyethyl)amino]ethyl nitrate
Identifiers
ChemSpider
ECHA InfoCard
100.027.615
UNII
InChI=1S/C6H12N4O9/c11-8(12)17-4-1-7(2-5-18-9(13)14)3-6-19-10(15)16/h1-6H2
Y Key: HWKQNAWCHQMZHK-UHFFFAOYSA-N
Y
C(CO[N+](=O)[O-])N(CCO[N+](=O)[O-])CCO[N+](=O)[O-]
Properties
C6 H12 N4 O9
Molar mass
284.18 g/mol
Pharmacology
C01DA09 (WHO )
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Trolnitrate (triethanolamine trinitrate , commonly used in the form of biphosphate salt also known as metamine) is an organic nitrate with vasodilator activity that is used to prevent or ameliorate attacks of angina pectoris.[ 1] Trolnitrate dilates the coronary vessels because of its basic action as a smooth muscle depressant, just as do nitroglycerin and other organic nitrates.[ 2]
References
Forms Targets
NO donors (prodrugs )
NONOates (diazeniumdiolates): Diethylamine/NO (DEA/NO)
Diethylenetriamine/NO (DETA/NO)
GLO/NO
JS-K
Methylamine hexamethylene methylamine/NO (MAHMA/NO)
PROLI/NO
Spermine/NO (SPER/NO)
V-PYRRO/NO
Unsorted: Cimlanod
FK-409
FR144220
FR146881
N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
Enzyme (inhibitors )
NOS
nNOS iNOS
1-Amino-2-hydroxyguanidine
2-Ethylaminoguanidine
2-Iminopiperidine
1400W
AEITU
Aminoguanidine (pimagedine)
AMT
AR-C 102222
BYK-191023
Canavanine
Cindunistat (SD-6010)
EITU
IPTU
MITU
N5 -(1-Iminoethyl)-L -ornithine (L -NIO)
N6 -(1-Iminoethyl)-L -lysine (L -NIL)
Nω -Methyl-L -arginine (L -NMA)
Ronopterin (VAS-203)
TRIM
eNOS Unsorted
Arginase CAMK
Others
Precursors: L -Arginine
Nω -Hydroxy-L -arginine (NOHA)
Indirect/downstream NO modulators: ACE inhibitors /AT-II receptor antagonists (e.g., captopril , losartan )
ETB receptor antagonists (e.g., bosentan )
L-Type calcium channel blockers (e.g., dihydropyridines : nifedipine )
Nebivolol (beta blocker )
PDE5 inhibitors (e.g., sildenafil )
non-selective PDE inhibitors (e.g., caffeine )
PDE9 inhibitors (e.g., paraxanthine )
cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)
Statins (e.g., simvastatin )
See also: Receptor/signaling modulators