Sozinibercept
| Clinical data | |
|---|---|
| Other names | OPT-302 |
| Routes of administration | Intravitreal |
| Drug class | VEGF-C and VEGF-D inhibitor |
| Legal status | |
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Sozinibercept was an investigational drug intended to be used to treat certain eye conditions such as wet age-related macular degeneration (AMD). It is administered intravitreally in combination with other Anti-VEGF-A including aflibercept, faricimab, ranibizumab, and bevacizumab.[1] It is developed by Opthea. It was granted Fast track designation by the United States Food and Drug Administration (FDA).[2]
Sozinibercept is a “trap” fusion protein that targets vascular endothelial growth factors C and D (VEGF-C and VEGF-D), aiming to inhibit abnormal blood vessel growth and fluid leakage in retinal diseases such as wet age-related macular degeneration (AMD).[3] Sozinibercept is synergistic with anti–VEGF-A therapies because it targets and neutralizes VEGF-C and VEGF-D, while anti–VEGF-A drugs inhibit only VEGF-A; this combined blockade suppresses a broader range of VEGF-driven pathways involved in abnormal blood vessel growth and vascular leakage in retinal diseases.[3]
Despite promising results in early-phase clinical trials, recent late-stage trials failed to meet their primary endpoints for vision improvement, leading to the discontinuation of its development for wet AMD.[4]
References
- ^ "Sozinibercept (OPT-302) for Wet AMD". Corporate Presentation. Opthea Limited.
- ^ Iapoce C (February 19, 2025). "Sozinibercept Topline Results Expected in Q2 After COAST Trial Completion". HCP Live.
- ^ a b Leitch IM, Gerometta M, Eichenbaum D, Finger RP, Steinle NC, Baldwin ME (July 2024). "Vascular Endothelial Growth Factor C and D Signaling Pathways as Potential Targets for the Treatment of Neovascular Age-Related Macular Degeneration: A Narrative Review". Ophthalmology and Therapy. 13 (7): 1857–1875. doi:10.1007/s40123-024-00973-4. PMC 11178757. PMID 38824253.
- ^ Iapoce C (25 March 2025). Brooks A (ed.). "Sozinibercept for Wet AMD Misses Primary Endpoint in Phase 3 COAST Trial". HCP Live.