Scott M. Grundy

Scott M. Grundy
Scott M. Grundy
Born
Scott Montgomery Grundy

(1933-07-10)July 10, 1933
Memphis, Texas
DiedJanuary 29, 2025(2025-01-29) (aged 91)
Alma materTexas Tech University (BS)
Baylor College of Medicine (MS) (MD)
Rockefeller University (PhD)
Scientific career
FieldsCardiology, Human nutrition, Lipidology
InstitutionsUniversity of Texas Southwestern Medical Center

Scott M. Grundy (10 July 1933 – 29 January 2025) was an American physician and researcher in cardiovascular medicine and nutrition science. He conducted research on cholesterol metabolism and was involved in the development of national and international guidelines for the prevention of atherosclerotic cardiovascular disease (ASCVD). Grundy's work explored the role of low-density lipoprotein (LDL) cholesterol, also known as “bad” cholesterol, in heart disease and the clinical use of statins.

Early life and education

Scott Montgomery Grundy was born July 10, 1933, in Memphis, Texas, to Beulah and Allen Grundy. After Allen's passing, Beulah raised Scott along with his siblings, Larry, and Elizabeth. In his early years, Dr. Grundy played basketball and baseball, receiving a college athletic scholarship. After completing his undergraduate education, he married Lois Parker (1936–2024), a special education professional. Together, they had two children; Stephan (1967–2021) and Pamela (1962–).[1]

He earned a Bachelor of Science from Texas Technological College, now Texas Tech University, in 1955, followed by a combined Master of Science and medical degree with honors from Baylor College of Medicine in 1960. He completed a Ph.D. at Rockefeller University in 1968, focusing on lipid metabolism.[1][2]

Career

Dr. Scott Grundy held leadership roles at several major government-funded and academic institutions. From 1971 to 1973, he directed the Metabolic Division at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in Phoenix, Arizona. He then led the Metabolic Disease Laboratory at the Veterans Administration Hospital affiliated with the University of California, San Diego until 1981. He later became the Founding Director of the Center for Human Nutrition (1981–2013) at the University of Texas Southwestern Medical Center (UTSW), where he also chaired the Department of Clinical Nutrition and served as a professor of Biochemistry and Internal Medicine (1981–2015). He also directed the Metabolic Unit and Endocrine Clinic at the Dallas Veterans Affairs Medical Center.[1][2]

Grundy served on numerous committees of the American Heart Association (AHA), including the Council on Arteriosclerosis, Thrombosis and Vascular Biology (ATVB), Nutrition Committee, Task Force on Risk Reduction, and Task Force on Cholesterol. He was one of the original founding members of the AHA's Nutrition, Physical Activity and Metabolism (NPAM) Council, now the Council on Lifestyle and Cardiometabolic Health. He was a Fellow of the National Lipid Association (FNLA) and certified by the American Board of Clinical Lipidologists (ABCL).[3] He was also a member of the International Atherosclerosis Society (IAS), the National Academy of Medicine, and the Texas Academy of Medicine, Engineering, Science, and Technology (TAMEST).[1][2]

Public health policy

Grundy contributed to the development of public nutrition policies and clinical guidelines for cholesterol management. In 1985, he was involved in the formation of the National Cholesterol Education Program (NCEP) under the National Heart, Lung, and Blood Institute (NHLBI). He chaired the Adult Treatment Panels (ATP II and III) of the NCEP, which issued evidence-based recommendations for managing high LDL cholesterol levels.[4][5] In 2005, Grundy and his colleagues contributed to the establishment of diagnostic criteria and treatment strategies for metabolic syndrome at the NHLBI/AHA conference.[6] He also co-chaired the 2018 multi-society Guideline on the Management of Blood Cholesterol, issued by a joint task force of the American College of Cardiology and the AHA.[7]

Research

Grundy published research on topics related nutrition, cardiovascular health, and cholesterol metabolism, including studies with Michael Stuart Brown and Joseph L. Goldstein.[8][9][10]

His work contributed to the lipid hypothesis, positing that elevated LDL cholesterol is a primary cause of atherosclerosis.[1] This hypothesis has been examined through decades of epidemiological research and randomized controlled trials, particularly those involving statin therapy.[11]

Grundy conducted clinical research in three primary areas: (a) cholesterol, triglycerides, and lipoprotein metabolism; (b) the impact of dietary fats on lipid metabolism; and (c) obesity and metabolic syndrome.

Honors and awards

UTSW has named several professorships for him: Scott Grundy Director's Chair and Dr. Scott M. Grundy Distinguished Professorship in Human Nutrition.[25]

The American Heart Association annually awards the Scott Grundy Fellowship Award for Excellence in Metabolism Research to recognize abstracts on diabetes, lipids and lipoproteins, or obesity and adipose tissue distribution.[26]

References

  1. ^ a b c d e Grundy, S. M. (1999-01-15). "Scott Montgomery Grundy, MD: a conversation with the editor∗∗This series of interviews underwritten by an unrestricted grant from Bristol-Myers Squibb". The American Journal of Cardiology. 83 (2): 223–241. doi:10.1016/S0002-9149(98)00849-2. PMID 10073825.
  2. ^ a b c d e f g Stone, Neil J.; Blumenthal, Roger S.; Brown, William Virgil; Cuevas, Ada; Gotto, Antonio M.; Orringer, Carl E.; Smith, Sidney C.; Vega, Gloria L. (2025-01-01). "In memoriam: A tribute to Dr Scott M. Grundy". Journal of Clinical Lipidology. 19 (1): 3–6. doi:10.1016/j.jacl.2025.02.006. ISSN 1933-2874.
  3. ^ a b "Past Award Winners | National Lipid Association Online". www.lipid.org. Retrieved 2025-08-04.
  4. ^ Grundy, S. M. (1994). "Guidelines for cholesterol management: recommendations of the National Cholesterol Education Program's Adult Treatment Panel II". Heart Disease and Stroke: A Journal for Primary Care Physicians. 3 (3): 123–127. ISSN 1058-2819. PMID 8044423.
  5. ^ a b National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002-12-17). "Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report". Circulation. 106 (25): 3143–3421. doi:10.1161/circ.106.25.3143. ISSN 1524-4539. PMID 12485966.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ a b Grundy, Scott M.; Cleeman, James I.; Daniels, Stephen R.; Donato, Karen A.; Eckel, Robert H.; Franklin, Barry A.; Gordon, David J.; Krauss, Ronald M.; Savage, Peter J.; Smith, Sidney C.; Spertus, John A.; Costa, Fernando (2005-10-25). "Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement". Circulation. 112 (17): 2735–2752. doi:10.1161/CIRCULATIONAHA.105.169404. ISSN 0009-7322. PMID 16157765.
  7. ^ Grundy, Scott M.; Stone, Neil J.; Bailey, Alison L.; Beam, Craig; Birtcher, Kim K.; Blumenthal, Roger S.; Braun, Lynne T.; de Ferranti, Sarah; Faiella-Tommasino, Joseph; Forman, Daniel E.; Goldberg, Ronald; Heidenreich, Paul A.; Hlatky, Mark A.; Jones, Daniel W.; Lloyd-Jones, Donald (2019-06-25). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary". Journal of the American College of Cardiology. 73 (24): 3168–3209. doi:10.1016/j.jacc.2018.11.002. PMID 30423391.
  8. ^ Bilheimer, D W; Goldstein, J L; Grundy, S M; Brown, M S (1975-12-01). "Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia". Journal of Clinical Investigation. 56 (6): 1420–1430. doi:10.1172/JCI108223. ISSN 0021-9738. PMC 333120. PMID 172531.
  9. ^ Bilheimer, D W; Grundy, S M; Brown, M S; Goldstein, J L (1983). "Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes". Proceedings of the National Academy of Sciences. 80 (13): 4124–4128. Bibcode:1983PNAS...80.4124B. doi:10.1073/pnas.80.13.4124. ISSN 0027-8424. PMC 394213. PMID 6575399.
  10. ^ Bilheimer, David W.; Goldstein, Joseph L.; Grundy, Scott M.; Starzl, Thomas E.; Brown, Michael S. (1984-12-27). "Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia". New England Journal of Medicine. 311 (26): 1658–1664. doi:10.1056/NEJM198412273112603. ISSN 0028-4793. PMC 2975980. PMID 6390206.
  11. ^ Grundy, Scott M. (1999). Cholesterol-Lowering Clinical Trials: A Historical Perspective (1st ed.). CRC Press. pp. 19–80. ISBN 9780367399320.
  12. ^ Metzger, Allan L.; Adler, Ronald; Heymsfield, Steven; Grundy, Scott M. (1973-02-15). "Diurnal Variation in Biliary Lipid Composition: Possible Role in Cholesterol Gallstone Formation". New England Journal of Medicine. 288 (7): 333–336. doi:10.1056/NEJM197302152880702. ISSN 0028-4793. PMID 4682942.
  13. ^ Grundy, Scott M.; Metzger, Allan L.; Adler, Ronald D. (1972-12-01). "Mechanisms of Lithogenic Bile Formation in American Indian Women with Cholesterol Gallstones". Journal of Clinical Investigation. 51 (12): 3026–3043. doi:10.1172/JCI107130. ISSN 0021-9738. PMC 332985. PMID 4640946.
  14. ^ Grundy, Scott M.; Vega, Gloria Lena (1990), Andreucci, Vittorio E.; Fine, Leon G.; Kjellstrand, Carl M.; Sugino, Nobuhiro (eds.), "Management of the Hyperlipidemia of the Nephrotic Syndrome", International Yearbook of Nephrology 1990, Boston, MA: Springer US, pp. 53–69, doi:10.1007/978-1-4613-1491-2_4, ISBN 978-1-4612-8802-2, retrieved 2025-07-21
  15. ^ Grundy, Scott M. (October 1991). "Hypertriglyceridemia: Examining its role in coronary heart disease". Postgraduate Medicine. 90 (5): 201–210. doi:10.1080/00325481.1991.11701084. ISSN 0032-5481. PMID 1924008.
  16. ^ Kesaniemi, Y. A.; Grundy, S. M. (1982-07-01). "Significance of low density lipoprotein production in the regulations of plasma cholesterol level in man". The Journal of Clinical Investigation. 70 (1): 13–22. doi:10.1172/jci110585. ISSN 0021-9738. PMC 370220. PMID 7085881.
  17. ^ Grundy, S M (November 1991). "George Lyman Duff Memorial Lecture. Multifactorial etiology of hypercholesterolemia. Implications for prevention of coronary heart disease". Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 11 (6): 1619–1635. doi:10.1161/01.ATV.11.6.1619. ISSN 1049-8834. PMID 1931866.
  18. ^ Grundy, Scott M.; Brewer, H. Bryan; Cleeman, James I.; Smith, Sidney C.; Lenfant, Claude (2004-01-27). "Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition". Circulation. 109 (3): 433–438. doi:10.1161/01.CIR.0000111245.75752.C6. ISSN 0009-7322. PMID 14744958.
  19. ^ Grundy, Scott M. (2014-11-01). "Statins for All?". The American Journal of Cardiology. 114 (9): 1443–1446. doi:10.1016/j.amjcard.2014.08.032. PMID 25245412.
  20. ^ Lakoski, Susan G.; Xu, Fang; Vega, Gloria L.; Grundy, Scott M.; Chandalia, Manisha; Lam, Chun; Lowe, Robert S.; Stepanavage, Michael E.; Musliner, Thomas A.; Cohen, Jonathan C.; Hobbs, Helen H. (2010-02-01). "Indices of Cholesterol Metabolism and Relative Responsiveness to Ezetimibe and Simvastatin". The Journal of Clinical Endocrinology & Metabolism. 95 (2): 800–809. doi:10.1210/jc.2009-1952. ISSN 0021-972X. PMC 3079219. PMID 19965915.
  21. ^ "Pioneer in Prevention Award - American Society for Preventive Cardiology". www.aspconline.org. Retrieved 2025-07-21.
  22. ^ a b "Previous Distinguished Scientist Recipients". professional.heart.org. Retrieved 2025-07-21.
  23. ^ "Past ASN and ASN Foundation Awards2023 Award Honorees - American Society for Nutrition". American Society for Nutrition. 2024-01-09. Archived from the original on 2024-10-29. Retrieved 2025-07-21.
  24. ^ SoRelle, Ruth (1998-02-24). "Award for Dr Scott Grundy". Circulation. 97 (7): 627. doi:10.1161/01.CIR.97.7.627. ISSN 0009-7322.
  25. ^ "In Memoriam: Scott M. Grundy, M.D., Ph.D., founding Director of the Center for Human Nutrition: Center Times Plus, UT Southwestern". www.utsouthwestern.edu. Retrieved 2025-08-04.
  26. ^ "Scott Grundy Fellowship Award for Excellence in Metabolism Research". professional.heart.org. Retrieved 2025-07-21.


Grundy published many scholarly works over the course of his career. For a more complete list of his publications, see:

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