Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.[5][6] It is one of three forms of 5α-reductase. Unlike SRD5A1 and SRD5A2, SRD5A3 has no apparent form in androgen processing or signaling. Instead, SRD5A3 reduces polyprenol to dolichol, which is necessary for N-linked glycosylation of proteins and some lipids.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000128039 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029233 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: steroid 5 alpha-reductase 3".
- ^ Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, et al. (January 2008). "Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer". Cancer Science. 99 (1): 81–86. doi:10.1111/j.1349-7006.2007.00656.x. PMC 11158902. PMID 17986282. S2CID 51733620.
- ^ Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, et al. (July 2010). "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder". Cell. 142 (2): 203–217. doi:10.1016/j.cell.2010.06.001. PMC 2940322. PMID 20637498.
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