SLC12A7

SLC12A7
Identifiers
Aliases	SLC12A7, KCC4, solute carrier family 12 member 7
External IDs	OMIM: 604879; MGI: 1342283; HomoloGene: 21312; GeneCards: SLC12A7; OMA:SLC12A7 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,112,063 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,964,873 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; left ventricle; ; right lobe of liver; ; gallbladder; ; duodenum; ; right auricle of heart; ; human kidney; ; body of stomach; ; spleen; ; granulocyte;
	Top expressed in
	vestibular membrane of cochlear duct; ; right ventricle; ; myocardium of ventricle; ; transitional epithelium of urinary bladder; ; cardiac muscle tissue of left ventricle; ; lumbar spinal ganglion; ; epithelium of stomach; ; left lobe of liver; ; interventricular septum; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; cation:chloride symporter activity; symporter activity; protein kinase binding; potassium:chloride symporter activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; protein-containing complex;
Biological process	potassium ion transport; cell volume homeostasis; chloride transmembrane transport; chemical synaptic transmission; potassium ion transmembrane transport; transmembrane transport; ion transport; chloride ion homeostasis; potassium ion homeostasis; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	10723
	20499
	ENSG00000276482; ENSG00000113504
	ENSMUSG00000017756
	Q9Y666
	Q9WVL3
	NM_006598
	NM_011390; NM_001360694
	NP_006589
	NP_035520; NP_001347623
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene.^[5]^[6]

References

^ ^a ^b ^c ENSG00000113504 GRCh38: Ensembl release 89: ENSG00000276482, ENSG00000113504 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017756 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mount DB, Mercado A, Song L, Xu J, George AL, Delpire E, Gamba G (June 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". The Journal of Biological Chemistry. 274 (23): 16355–62. doi:10.1074/jbc.274.23.16355. PMID 10347194.
^ "Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7".

Mercado A, Song L, Vazquez N, Mount DB, Gamba G (September 2000). "Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4". The Journal of Biological Chemistry. 275 (39): 30326–34. doi:10.1074/jbc.M003112200. PMID 10913127.
Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (December 2000). "Characterization of long cDNA clones from human adult spleen". DNA Research. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
Boettger T, Hübner CA, Maier H, Rust MB, Beck FX, Jentsch TJ (April 2002). "Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4". Nature. 416 (6883): 874–8. Bibcode:2002Natur.416..874B. doi:10.1038/416874a. PMID 11976689. S2CID 4389928.
Bräuer M, Frei E, Claes L, Grissmer S, Jäger H (July 2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts". American Journal of Physiology. Cell Physiology. 285 (1): C22-30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.
Karadsheh MF, Byun N, Mount DB, Delpire E (2004). "Localization of the KCC4 potassium-chloride cotransporter in the nervous system". Neuroscience. 123 (2): 381–91. doi:10.1016/j.neuroscience.2003.10.004. PMID 14698746. S2CID 41970238.
Shen MR, Lin AC, Hsu YM, Chang TJ, Tang MJ, Alper SL, Ellory JC, Chou CY (September 2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". The Journal of Biological Chemistry. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.
Hsu YM, Chou CY, Chen HH, Lee WY, Chen YF, Lin PW, Alper SL, Ellory JC, Shen MR (March 2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". Journal of Cellular Physiology. 210 (3): 626–36. doi:10.1002/jcp.20859. PMID 17133354. S2CID 21615465.

[refGRCh38Ensembl-1] ENSG00000113504 GRCh38: Ensembl release 89: ENSG00000276482, ENSG00000113504 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017756 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10347194-5] Mount DB, Mercado A, Song L, Xu J, George AL, Delpire E, Gamba G (June 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". The Journal of Biological Chemistry. 274 (23): 16355–62. doi:10.1074/jbc.274.23.16355. PMID 10347194.

[entrez-6] "Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7".

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[4]

[5]

[6]

SLC12A7

See also

References

Further reading