RRNA N-glycosylase
| rRNA N-glycosylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Ricin A chain, Ricinus communis | |||||||||
| Identifiers | |||||||||
| EC no. | 3.2.2.22 | ||||||||
| CAS no. | 113756-12-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
rRNA N-glycosylase (EC 3.2.2.22, ribosomal ribonucleate N-glycosidase, nigrin b, RNA N-glycosidase, rRNA N-glycosidase, ricin, momorcochin-S, Mirabilis antiviral protein, gelonin, saporins) is an enzyme with systematic name rRNA N-glycohydrolase.[1] This enzyme catalyses the following chemical reaction
- Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from eukaryotic ribosomes.
Ricin A-chain and related toxins show this activity. The only protein family known to have this activity is the ribosome-inactivating protein (RIP) family.
References
- ^ Endo Y, Tsurugi K (June 1988). "The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA". The Journal of Biological Chemistry. 263 (18): 8735–9. doi:10.1016/S0021-9258(18)68367-X. PMID 3288622.
External links
- RRNA+N-glycosylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)