REST corepressor 2 also known as CoREST2 is a protein that in humans is encoded by the RCOR2 gene.[5]
CoREST2 is a transcriptional corepressor protein that plays a pivotal role in regulating gene expression critical for stem cell pluripotency,[6] neurogenesis,[7] and cell fate determination. Predominantly expressed in embryonic stem cells and the central nervous system, RCOR2 partners with key complexes such as LSD1 to modulate chromatin structure and repress target genes, ensuring proper cell proliferation and differentiation.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167771 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024968 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: RCOR2 – REST corepressor 2".
- ^ Yang P, Wang Y, Chen J, Li H, Kang L, Zhang Y, et al. (May 2011). "RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to pluripotency". Stem Cells. 29 (5). Dayton, Ohio: 791–801. doi:10.1002/stem.634. PMID 21433225.
- ^ Lam XJ, Maniam S, Cheah PS, Ling KH (October 2023). "REST in the Road Map of Brain Development". Cellular and Molecular Neurobiology. 43 (7): 3417–3433. doi:10.1007/s10571-023-01394-w. PMC 11410019. PMID 37517069.
