Pyostomatitis vegetans

Pyostomatitis vegetans is an inflammatory stomatitis and most often seen in association with inflammatory bowel disease, namely ulcerative colitis and Crohn's disease.[1][2] Uncommonly, it may be one of the features of orofacial granulomatosis.[3]

Diagnosis

Features that are helpful in establishing the diagnosis of pyostomatitis vegetans are snail track appearance of oral lesions, an associated IBD (which is not always symptomatic), evidence of intraepithelial clefting on microscopic examination of oral lesions, and peripheral blood eosinophilia.[4]

Treatment

There is no established therapeutic protocol for PSV and management primarily consists of topical and/or systemic corticosteroids, antirheumatic drugs (sulfasalazine, mesalazine), monoclonal antibody (infliximab, adalimumab) immunosuppressives (azathioprine, methotrexate), antibiotics (dapsone), or a combination of these.[4]

See also

References

  1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. p. 798. ISBN 978-0-7216-2921-6.
  2. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 389. ISBN 978-1-4160-2999-1.
  3. ^ Leão, JC; Hodgson, T; Scully, C; Porter, S (Nov 15, 2004). "Review article: orofacial granulomatosis". Alimentary Pharmacology & Therapeutics. 20 (10): 1019–27. doi:10.1111/j.1365-2036.2004.02205.x. PMID 15569103.
  4. ^ a b Chrcanovic, Bruno Ramos; Martins-Chaves, Roberta Rayra; Pontes, Flávia Sirotheau Correa; Fonseca, Felipe Paiva; Pontes, Hélder Antônio Rebelo; Gomez, Ricardo Santiago (2024-03-12). "Pyodermatitis-pyostomatitis vegetans: a case report and systematic review focusing on oral involvement". Oral and Maxillofacial Surgery. 28 (3): 1405–1414. doi:10.1007/s10006-024-01234-1. ISSN 1865-1569. PMC 11330387. PMID 38467949.  This article incorporates text available under the CC BY 4.0 license.


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