RNA polymerase III subunit B is an enzyme which is encoded by the gene POLR3B is a gene that in humans encodes the second largest subunit of RNA polymerase III.[5]
Gene
The POLR3B gene is located on the long arm (q) of chromosome 12 on position 23.3, from base pair from base pair 106,357,748 to base pair 106,510,198.[6]
Function
RNA polymerase III essential enzyme complex responsible for synthesizing small non-coding RNAs, including transfer RNAs (tRNAs) and 5S ribosomal RNA (rRNA) and these small RNAs play a critical role in the process of protein synthesis within cells.[7]
Clinical significance
Mutations in POLR3B are associated with certain genetic disorders, such as hypomyelinating leukodystrophy and Charcot–Marie–Tooth disease type 1I, highlighting its importance in normal nervous system development and function.[7][8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000013503 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034453 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "POLYMERASE III, RNA, SUBUNIT B; POLR3B". omim.org.
- ^ "POLR3B RNA polymerase III subunit B [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2025-07-31.
- ^ a b "POLR3B gene: MedlinePlus Genetics". MedlinePlus. U.S. National Library of Medicine.
- ^ Lata E, Choquet K, Sagliocco F, Brais B, Bernard G, Teichmann M (2021). "RNA Polymerase III Subunit Mutations in Genetic Diseases". Frontiers in Molecular Biosciences. 8: 696438. doi:10.3389/fmolb.2021.696438. PMC 8362101. PMID 34395528.
