Grey's Anatomy season 22

Grey's Anatomy
Season 22
ShowrunnerMeg Marinis
Starring
Release
Original networkABC
Original releaseOctober 9, 2025 (2025-10-09)
Season chronology

The twenty-second season of the American medical drama television series Grey's Anatomy was announced on April 3, 2025, and premieres in the United States on the American Broadcasting Company (ABC) on October 9, 2025.[1][2]

This is the first season not to feature Jake Borelli and Midori Francis as series regulars since the sixteenth and nineteenth seasons, respectively.[3]

Cast and characters

See also: List of Grey's Anatomy cast members and List of Grey's Anatomy characters

Main

Recurring

Guest

Episodes

See also: List of Grey's Anatomy episodes
No.
overall		No. in
season		Title [6]Directed byWritten by [7]Original release date [6]U.S. viewers
(millions)
4491TBADebbie AllenMeg MarinisOctober 9, 2025 (2025-10-09)TBD
4502TBAKevin McKiddTBAOctober 16, 2025 (2025-10-16)TBD
4513TBATBATBAOctober 23, 2025 (2025-10-23)TBD
4524TBATBATBAOctober 30, 2025 (2025-10-30)TBD

Production

Development

On April 3, 2025, ABC renewed the series for a twenty-second season with Meg Marinis third year as showrunner.[1] The season consists of 18 episodes, consistent with the episode order of Season 21.[8] It will also surpass the 450 episode mark during episode 2, extending its record as the longest-running American primetime medical drama.[9] Filming began on August 1.[10] Season 22 premieres in the United States on October 9, 2025.[11]

Casting

Ellen Pompeo will continue to narrate the series and receive star billing, appearing in seven episodes, as she did in Season 21.[12] Chandra Wilson and James Pickens Jr. remain the only original cast members confirmed to appear in all 18 episodes.[13]

Reception

Ratings

Viewership and ratings per episode of Grey's Anatomy season 22
No. Title Air date Timeslot (ET) Rating/share
(18–49)		 Viewers
(millions)		 DVR
(18–49)		 DVR viewers
(millions)		 Total
(18–49)		 Total viewers
(millions)
1 "TBA" October 9, 2025 Thursday
10:00 p.m.		 — — — — — —
2 "TBA" October 16, 2025 — — — — — —
3 "TBA" October 23, 2025 — — — — — —
4 "TBA" October 30, 2025 — — — — — —
5 "TBA" November 6, 2025 — — — — — —
6 "TBA" November 13, 2025 — — — — — —
7 "TBA" November 20, 2025 — — — — — —
8 "TBA" December 4, 2025 — — — — — —

References

  1. ^ a b Otterson, Joe (April 3, 2025). "'9-1-1,' 'Grey's Anatomy,' 'The Rookie,' 'Shifting Gears,' 'Will Trent' Renewed at ABC". Variety. Retrieved July 15, 2025.
  2. ^ White, Peter (July 29, 2025). "ABC Moves Up 'Grey's Anatomy', '9-1-1' & '9-1-1: Nashville' Premiere Dates". Deadline Hollywood. Retrieved July 29, 2025.
  3. ^ Venable, Malcom (December 4, 2024). "'Grey's Anatomy' Showrunner Meg Marinis on That Shocking Mid-Season Finale, Two Big Departures, and What's Coming Next". Shondaland. Retrieved July 22, 2025.
  4. ^ Andreeva, Nellie (April 1, 2025). "'Grey's Anatomy': Trevor Jackson Joins Cast Of ABC Medical Drama". Deadline Hollywood. Retrieved July 21, 2025.
  5. ^ Andreeva, Nellie (May 15, 2025). "'Grey's Anatomy' Delivers Explosive Season 21 Finale Cliffhanger: Meg Marinis On Lives In Danger, Couples At Crossroads, New Cast Addition & More". Deadline Hollywood. Retrieved July 21, 2025.
  6. ^ a b "Shows A-Z – Grey's Anatomy on ABC". The Futon Critic. Retrieved April 16, 2025.
  7. ^ "Grey's Anatomy". Writers Guild of America West. Retrieved February 23, 2025.
  8. ^ Andreeva, Nellie (April 3, 2025). "'Grey's Anatomy' Renewed For Season 22 By ABC With Veteran Cast Poised To Return". Deadline Hollywood. Retrieved July 21, 2025.
  9. ^ Levine, Daniel; Hyman, Lizzie (May 14, 2025). "Chandra Wilson Says After 20 Years, 'It Is Time' to Watch Grey's Anatomy for Herself: 'Got as Far as Season 3' (Exclusive)". People Magazine. Retrieved July 21, 2025.
  10. ^ Camilla Luddington [@camillaluddington]; (July 31, 2025). "Backstory… Tonight I'm re-watching the season finale again to prepare for filming tmw. And suddenly.. Matt decides he needs to blend a smoothie. At 8pm.. during this scene.. I had to start recording 😂". Retrieved August 10, 2025 – via Instagram.
  11. ^ Shanfeld, Ethan (July 29, 2025). "'Grey's Anatomy,' '9-1-1' and '9-1-1: Nashville' Move Up Premiere Dates on ABC". Variety. Retrieved July 29, 2025.
  12. ^ Gao, Max (April 29, 2025). "Ellen Pompeo on Her Lasting Legacy, the 'Really S—ty' Streaming Residual Model and Meredith's Choice This Season She Was 'Deeply Against'". Variety. Retrieved July 21, 2025.
  13. ^ Bell, Amanda (July 17, 2025). "'Grey's Anatomy' Season 22 Premiere Date Revealed". TV Insider. Retrieved July 21, 2025.
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