Ceramide glucosyltransferase
Ceramide glucosyltransferase (or glucosylceramide synthase) is a glucosyltransferase enzyme involved in the production of glucocerebrosides (also called glucosylceramides). It is responsible for the first step in synthesis of all glycosphingolipids—critical components of cell membranes—from sphingolipids, attaching a glucose molecule (glycosylation) to produce a glucocerebroside product.[1] The enzyme is classified under EC 2.4.1.80.
References
- ^ Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (May 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4638–43. Bibcode:1996PNAS...93.4638I. doi:10.1073/pnas.93.10.4638. PMC 39331. PMID 8643456.
External links
- Ceramide+glucosyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)