Daf-3

Dwarfin sma
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-3
Entrez180431
RefSeq (mRNA)NM_075760.6
RefSeq (Prot)NP_508161.3
UniProtQ95QI7
Other data
ChromosomeX: 0.82 - 0.83 Mb
Search for
StructuresSwiss-model
DomainsInterPro

The DAF-3 or Dwarfin sma is a nematode Caenorhabditis elegans gene encoding a Co-SMAD protein of TGF-beta signaling pathway. Without daf-7 signal, DAF-3 combined with transcription factor daf-5 to form a heterodimer and started dauer development. When daf-7 binds to the receptors daf-1/daf-4, the phosphorylated daf-8/daf-14 heterodimer enter to the nucleus to inhibit this transcription.[1]

References

  1. ^ Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.
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