BAY 36-7620

BAY 36-7620^[1]
Names
	IUPAC name (3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one
Identifiers
CAS Number	232605-26-4;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL254372;
ChemSpider	8079411;
IUPHAR/BPS	1381;
PubChem CID	9903757;
UNII	0P934RSF8B;
	InChI InChI=1S/C19H18O2/c1-13-8-17-12-21-18(20)19(17,10-13)11-14-6-7-15-4-2-3-5-16(15)9-14/h2-7,9,17H,1,8,10-12H2/t17-,19+/m1/s1 Key: CVIRWLJKDBYYOG-MJGOQNOKSA-N;
	SMILES C=C1C[C@@H]2COC(=O)[C@@]2(C1)CC3=CC4=CC=CC=C4C=C3;
Properties
Chemical formula	C19H18O2
Molar mass	278.351 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

BAY 36-7620 is an antagonist at mGluR1 receptors.^[2] It has a IC50 value of 160 nM at the receptor.^[3] This compound has been used to study metabotropic glutamate receptors, along with other chemicals.^[4]^[5]

Effects

When used on rats in vivo, BAY 36-7620 has anticonvulsant and neuroprotective effects, while lacking side effects present with ionotropic glutamate receptor antagonists.^[6]

References

^ PubChem. "Bay 367620". pubchem.ncbi.nlm.nih.gov. Retrieved 2025-08-02.
^ Schröder, U. H.; Müller, T.; Schreiber, R.; Stolle, A.; Zuschratter, W.; Balschun, D.; Jork, R.; Reymann, K. G. (2008-11-19). "The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice". Neuroscience. 157 (2): 385–395. doi:10.1016/j.neuroscience.2008.08.063. ISSN 0306-4522. PMID 18832015.
^ "AID 313149 - Antagonist activity at mGlu1 receptor - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2025-08-02.
^ Lavreysen, Hilde; Janssen, Cor; Bischoff, François; Langlois, Xavier; Leysen, Josée E.; Lesage, Anne S. J. (May 2003). "[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists". Molecular Pharmacology. 63 (5): 1082–1093. doi:10.1124/mol.63.5.1082. ISSN 0026-895X. PMID 12695537.
^ Leembruggen, Anita J. L.; Lu, Yuqing; Wang, Haozhe; Uzungil, Volkan; Renoir, Thibault; Hannan, Anthony J.; Stamp, Lincon A.; Hao, Marlene M.; Bornstein, Joel C. (2023-01-09). "Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon". Biomolecules. 13 (1): 139. doi:10.3390/biom13010139. ISSN 2218-273X. PMC 9856182. PMID 36671524.
^ De Vry, J.; Horváth, E.; Schreiber, R. (2001-10-05). "Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620". European Journal of Pharmacology. 428 (2): 203–214. doi:10.1016/s0014-2999(01)01296-1. ISSN 0014-2999. PMID 11675037.

[1] PubChem. "Bay 367620". pubchem.ncbi.nlm.nih.gov. Retrieved 2025-08-02.

[2] Schröder, U. H.; Müller, T.; Schreiber, R.; Stolle, A.; Zuschratter, W.; Balschun, D.; Jork, R.; Reymann, K. G. (2008-11-19). "The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice". Neuroscience. 157 (2): 385–395. doi:10.1016/j.neuroscience.2008.08.063. ISSN 0306-4522. PMID 18832015.

[3] "AID 313149 - Antagonist activity at mGlu1 receptor - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2025-08-02.

[4] Lavreysen, Hilde; Janssen, Cor; Bischoff, François; Langlois, Xavier; Leysen, Josée E.; Lesage, Anne S. J. (May 2003). "[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists". Molecular Pharmacology. 63 (5): 1082–1093. doi:10.1124/mol.63.5.1082. ISSN 0026-895X. PMID 12695537.

[5] Leembruggen, Anita J. L.; Lu, Yuqing; Wang, Haozhe; Uzungil, Volkan; Renoir, Thibault; Hannan, Anthony J.; Stamp, Lincon A.; Hao, Marlene M.; Bornstein, Joel C. (2023-01-09). "Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon". Biomolecules. 13 (1): 139. doi:10.3390/biom13010139. ISSN 2218-273X. PMC 9856182. PMID 36671524.

[6] De Vry, J.; Horváth, E.; Schreiber, R. (2001-10-05). "Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu(1) receptor antagonist BAY 36-7620". European Journal of Pharmacology. 428 (2): 203–214. doi:10.1016/s0014-2999(01)01296-1. ISSN 0014-2999. PMID 11675037.

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