2022 U.S. Men's Clay Court Championships – Singles

Singles
2022 U.S. Men's Clay Court Championships
Champion	Reilly Opelka
Runner-up	John Isner
Score	6–3, 7–6(9–7)
Draw	28 (4 Q / 3 WC)
Seeds	8

Reilly Opelka defeated John Isner in the final, 6–3, 7–6^(9–7), to win the singles tennis title at the 2022 U.S. Men's Clay Court Championships. It marked Opelka's fourth career Association of Tennis Professionals (ATP) singles title and his first on clay. With Opelka's height at 6 ft 11 in (211 cm) and Isner's at 6 ft 10 in (208 cm), the combined heights of both players made the final the tallest one ever contended during the Open Era. At the age of 36, Isner was also playing to become the oldest champion at the tournament in the Open Era.^[1]

Cristian Garín was the defending champion from when the tournament was last held in 2019,^[2] but lost in the semifinals to Isner.^[3]

The top four seeds received a bye into the second round.

	Semifinals							Final
	WC	Nick Kyrgios	3	5
	3	Reilly Opelka	6	7
								3	Reilly Opelka	6	79
								4	John Isner	3	67
	4	John Isner	4	6	6
	5	Cristian Garín	6	3	4

	First round							Second round							Quarterfinals							Semifinals
								LL	M Mmoh	6	6
		DE Galán	60	6	66				S Querrey	2	4
		S Querrey	77	3	78										LL	M Mmoh
		M McDonald	6	3	4										WC	N Kyrgios	w/o
	WC	N Kyrgios	4	6	6			WC	N Kyrgios	6	6
		P Gojowczyk	77	65	2r			7	T Paul	4	2
	7	T Paul	64	77	3																	WC	N Kyrgios	3	5
																						3	R Opelka	6	7
								3	R Opelka	3	6	6
	Q	M Krueger	5					Q	M Krueger	6	2	4
		JP Varillas	1r												3	R Opelka	6	7
	Q	G Brouwer	6	6											Q	G Brouwer	3	5
		F López	4	2				Q	G Brouwer	6	6
	WC	J. J. Wolf	6	6				WC	J. J. Wolf	1	1
	8	J Brooksby	4	4

	First round							Second round							Quarterfinals							Semifinals
	6	F Tiafoe	6	6
		M Giron	4	4				6	F Tiafoe	5	7	77
	Q	M Purcell	67	3					P Cuevas	7	5	64
		P Cuevas	79	6											6	F Tiafoe	4	6	3
		S Johnson	6	4	6										4	J Isner	6	2	6
		D Kudla	3	6	4				S Johnson	77	64	3
								4	J Isner	61	77	6
																						4	J Isner	4	6	6
	5	C Garín	4	6	7																	5	C Garín	6	3	4
	WC	J Sock	6	3	5			5	C Garín	3	6	6
		J Thompson	6	6					J Thompson	6	3	3
	LL	S Diez	3	2											5	C Garín	6	65	6
	Q	C Harrison	1	4											2	T Fritz	2	77	3
		A Tabilo	6	6					A Tabilo	1	4
								2	T Fritz	6	6

	First round							Qualifying competition
	1	Tomás Barrios Vera	4	2
		Gijs Brouwer	6	6
									Gijs Brouwer	4	7	6
								7	Steven Diez	6	5	2
		Zachary Svajda	3	2
	7	Steven Diez	6	6

	First round							Qualifying competition
	2	Bjorn Fratangelo	4	3
	WC	Ryan Harrison	6	6
								WC	Ryan Harrison	7	4	4
								8	Christian Harrison	5	6	6
	WC	Diego Hidalgo
	8	Christian Harrison	w/o

	First round							Qualifying competition
	3	Mitchell Krueger	7	6
		Matthew Ebden	5	1
								3	Mitchell Krueger	6	6
								5	Michael Mmoh	3	3
	Alt	Sadio Doumbia	2	77	1r
	5	Michael Mmoh	6	62	4

	First round							Qualifying competition
	4	Max Purcell	6	6
		Donald Young	2	2
								4	Max Purcell	4	6	6
									Moez Echargui	6	3	3
		Moez Echargui	6	4	77
	6	Gonzalo Lama	3	6	65

• Main draw
• Qualifying draw