2021 US Open – Wheelchair women's singles
| Wheelchair women's singles | |
|---|---|
| 2021 US Open | |
| Champion |  Diede de Groot |
| Runner-up |  Yui Kamiji |
| Score | 6–3, 6–2 |
| Draw | 8 |
| Seeds | 2 |
Three-time defending champion Diede de Groot[1] defeated Yui Kamiji in the final, 6–3, 6–2 to win the women's singles wheelchair tennis title at the 2021 US Open. With the win, she completed the Golden Slam, becoming the first wheelchair tennis player to do so (alongside Dylan Alcott in the quad singles event).
Seeds
- Diede de Groot (champion)
- Yui Kamiji (final)
Draw
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- ITF = ITF entry
- PR = Protected ranking
- SR = Special ranking
- SE = Special exempt
- JE = Junior exempt
- JR = Junior Accelerator Programme entrant
- CO = College Accelerator Programme entrant
- NG = Next Gen Accelerator Program entrant
- w/o = Walkover
- r = Retired
- d = Defaulted
Finals
| Quarterfinals | Semifinals | Final | ||||||||||||||||||
| 1 | Diede de Groot
| 6 | 6 | |||||||||||||||||
 Angélica Bernal
| 2 | 0 | ||||||||||||||||||
| 1 | Diede de Groot
| 6 | 6 | |||||||||||||||||
| Aniek van Koot
| 1 | 0 | ||||||||||||||||||
| Aniek van Koot
| 6 | 6 | ||||||||||||||||||
| WC |  Dana Mathewson
| 1 | 2 | |||||||||||||||||
| 1 | Diede de Groot
| 6 | 6 | |||||||||||||||||
| 2 | Yui Kamiji
| 3 | 2 | |||||||||||||||||
| Momoko Ohtani
| 1 | 7 | 3 | |||||||||||||||||
 Jordanne Whiley
| 6 | 5 | 6 | |||||||||||||||||
| Jordanne Whiley
| 1 | 3 | ||||||||||||||||||
| 2 | Yui Kamiji
| 6 | 6 | |||||||||||||||||
 Kgothatso Montjane
| 612 | 2 | ||||||||||||||||||
| 2 | Yui Kamiji
| 714 | 6 | |||||||||||||||||